产品货号：
Z10865
中文名称：
ANK1抗体
英文名称：
Anti-ANK1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ANK1 Antibody |
| 指标别名 | ANK;ANK 1;ANK1;Ankyrin 1;ankyrin 1;erythrocytic;Ankyrin R;Erythrocyte ankyrin;SPH1;SPH2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | ANK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Ankyrin erythroid/ANK/ANK1 recombinant protein (Position:N1300-Q1844). |
| 实际分子量 | 250KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Ankyrin 1,erythrocytic,also known as ANK1,is a protein that in humans is encoded by the ANK1 gene.Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility,activation,proliferation,contact and the maintenance of specialized membrane domains.Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific,developmentally regulated manner.Most ankyrins are typically composed of three structural domains:an amino-terminal domain containing multiple ankyrin repeats;a central region with a highly conserved spectrin binding domain;and a carboxy-terminal regulatory domain which is the least conserved and subject to variation.Ankyrin 1,the prototype of this family,was first discovered in the erythrocytes,but since has also been found in brain and muscles.Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis.Complex patterns of alternative splicing in the regulatory domain,giving rise to different isoforms of ankyrin 1 have been described.Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. |
| Uniprot ID | P16157 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | ankyrin 1 |
| 蛋白名全称 | Ankyrin-1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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